THESIS ON INTRATHECAL DEXMEDETOMIDINE

Conclusion Weighing the prolongation of anesthesia and analgesia and side effects we conclude that 10 mcg of dexmedetomidine is optimum intrathecal dose. The duration of analgesia was considered as the period from the injection of the study drug to the first request made by the patient for rescue analgesics. The study was conducted after approval of ethical committee of the institution. Data are expressed as either mean and standard deviation or numbers and percentages. Footnotes Source of Support: Strebel and colleagues suggested that a dose of mcg of clonidine was preferred dose with respect to prolonging spinal anaesthesia with bupivacaine without much side effects [ 2 ].

They found a shorter onset of motor block and a prolongation in the duration of motor and sensory block with haemodynamic stability and lack of sedation [ 5 ]. Hala EA Eid et al. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: Hence, if we require regional anaesthesia for longer duration we use some additive. Sedation score of 2 in many patients in group D3 and D4 and a few patients in D2 can be justified as alpha 2 agonists produce sedative effect by acting on alpha 2 adrenergic receptors in locus ceruleus [ 23 , 24 ]. J Anesth Clin Res. A regression model for identifying patients at high risk of hypotension, bradycardia and nausea during spinal anaesthesia.

C, D1, D2, D3 and D4 containing 20 patients. Abdelhamid and El-lakany evaluated the role of dexmedetomidine 5 mcg as adjuvant intrathecally and found it to decrease postoperative analgesic requirement, less shivering among patients of lower abdominal surgery [ 10 ].

Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult

We found that all patients receiving dexmedetomidine had less postoperative pain scores and longer duration of analgesia as compared to control group. Introduction Spinal anaesthesia is the most commonly performed block for lower abdominal, perineum and lower limb surgery. Visceral pain during caesarean section under spinal and epidural anaesthesia with bupivacaine.

  DISSERTATION SUR UEMOA

Sedation was assessed using Ramsay sedation scale [ 13 ] before the block and every 15 minutes. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. However, postoperative pain control is a major problem because spinal anesthesia using only local anesthetics is associated with dexmedetomidien short duration of action, and thus early analgesic intervention is needed in the postoperative period.

Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult

Gupta R et al. The analgesia was clinically better in group D as compared to group F but it was not statistically significant.

thesis on intrathecal dexmedetomidine

Spinal anaesthesia is the most commonly performed block for lower abdominal, perineum and lower limb surgery. Testing was then conducted every 10 min until the point of two segment regression of the block was observed.

thesis on intrathecal dexmedetomidine

Aim To find out the optimum dose of dexmedetomidine to be used in lower abdomen surgery intrathecally. In our study hypotension was more in the dexmedetomidine group than in the fentanyl group, but it was not statistically significant. A Double Blind Controlled Study. Effect of dexmedetomidine added to spinal bupivacaine for urological procedure.

All patients received drug volume of 3ml containing 2. Various adjuvants dexmedefomidine been used with local anesthetics in spinal anesthesia to avoid intraoperative visceral and somatic pain and to provide prolonged postoperative analgesia.

Hence, if we require regional anaesthesia for longer duration dexmedstomidine use some additive. Sin Shams Journal of Anaesthesiology. Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. Strebel and colleagues suggested that a dose of mcg of clonidine was preferred dose with respect to prolonging spinal anaesthesia with bupivacaine without much side effects [ 2 ].

Effect of low dose dexmedetomidine or clonidine on the characteristic of bupivacaine thhesis block. The use of dexmedetomjdine clonidine has been studied with local anesthetics. Hence we decided to take a dose of 20 mcg to compare it with 15 mcg of dexmedetomidine to see if this also gives haemodynamic stability and upto what extent it prolongs the analgesic effect of bupivacaine. The study was conducted from December to October The duration of analgesia was considered as the period from the injection of the study drug to the first request made by the patient for rescue analgesics.

  70-415 CASE STUDY

The number of intrathecaal patients increased in the groups that received higher dose of dexmdetomidine and so did the sedation score in the groups. Sensory testing was assessed by loss of pinprick sensation to 23G hypodermic needle and dermatomes levels were tested every 2 min until the highest level had stabilized tyesis consecutive tests.

thesis on intrathecal dexmedetomidine

Open in a separate window. The trend shows that both sensory and motor block onset time and the time for the block to reach T10 or the highest level decreases as the dose of dexmedetomidine increases. But one has to be vigilant because a good number of patients had a fall in heart rate and BP when 15 and 20 mcg dose of dexmedetomidine were used intrathecally.

Nausea and vomiting was noted in few patients of C, D2 and D3 and was treated by giving injection ondansetron 8 mg Complete recovery of sensory and motor function theesis seen in all the patients. But hhesis we use higher doses like 15mcg and 20mcg more vigilance is required due to higher incidence of hypotension and bradycardia.

Introduction Spinal anesthesia is the most commonly used technique for oh abdominal surgeries as it is very economical and easy to administer.